Sandbox Reserved 813: Difference between revisions
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{{Sandbox_Reserved_ESBS}} | {{Sandbox_Reserved_ESBS}} | ||
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==Your Heading Here (maybe something like 'Structure')==<StructureSection load='3l1p' size='500' side='right' caption='Structure of Oct-4 (PDB entry [[3l1p]])' scene=''> | |||
<big>'''OCT-4 or POU5F1'''</big> | <big>'''OCT-4 or POU5F1'''</big> | ||
= Introduction = | = Introduction = | ||
[http://en.wikipedia.org/wiki/Oct-4 Oct-4] for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mammalian totipotent embryonic stem and germ cells. Oct-4 is the only factor that cannot be replace by an other factor of the POU family to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells. | [http://en.wikipedia.org/wiki/Oct-4 Oct-4] for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mammalian totipotent embryonic stem and germ cells. Oct-4 is the only factor that cannot be replace by an other factor of the POU family to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells. | ||