Sandbox Reserved 818: Difference between revisions
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==Binding of pertussis toxin to its cellular targets== | ==Binding of pertussis toxin to its cellular targets== | ||
After being secreted by the Ptl machinery (a member of the [http://en.wikipedia.org/wiki/Secretion#Type_IV_secretion_system_.28T4SS_or_TFSS.29 type IV secretion system]), PTX can interact with almost all mammalian cells, which explains the variety of biological activities of the toxin. <br /> | After being secreted by the ''Ptl machinery'' (a member of the [http://en.wikipedia.org/wiki/Secretion#Type_IV_secretion_system_.28T4SS_or_TFSS.29 type IV secretion system]), PTX can interact with almost all mammalian cells, which explains the variety of biological activities of the toxin. <br /> | ||
No specific receptors for PTX have been identified but many cell surface [http://en.wikipedia.org/wiki/Sialoglycoprotein '''sialoglycoproteins'''] are involved in the binding of PTX | No specific receptors for PTX have been identified but many cell surface [http://en.wikipedia.org/wiki/Sialoglycoprotein '''sialoglycoproteins'''] are involved in the binding of PTX | ||
<ref name="Peppler (1988)"> | <ref name="Peppler (1988)"> | ||