4lnq: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4lnq| PDB=4lnq | SCENE= }} | {{STRUCTURE_4lnq| PDB=4lnq | SCENE= }} | ||
===Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA=== | ===Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA=== | ||
{{ABSTRACT_PUBMED_24419611}} | |||
==Function== | ==Function== | ||
| Line 9: | Line 10: | ||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024419611</ref><references group="xtra"/><references/> | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
[[Category: Wang, Z X.]] | [[Category: Wang, Z X.]] | ||
Revision as of 06:34, 13 February 2014
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNACrystal structure of Ifi202 HINa domain in complex with 20bp dsDNA
Template:ABSTRACT PUBMED 24419611
FunctionFunction
[IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.[1] [2]
About this StructureAbout this Structure
4lnq is a 4 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Li H, Wang J, Wang J, Cao LS, Wang ZX, Wu JW. Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):21-9. doi:, 10.1107/S2053230X1303135X. Epub 2013 Dec 24. PMID:24419611 doi:http://dx.doi.org/10.1107/S2053230X1303135X
- ↑ Xin H, D'Souza S, Jorgensen TN, Vaughan AT, Lengyel P, Kotzin BL, Choubey D. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70. PMID:16670293
- ↑ Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009, Jan 8. PMID:19131592 doi:10.1126/science.1169841