Sandbox Reserved 813: Difference between revisions
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{{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | |||
= Introduction = | = Introduction = | ||
Oct-4 for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mouse totipotent embryonic stem and germ cells. Oct 4 is the only factor that cannot be replace by an other factor of the POU family to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells. | Oct-4 for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mouse totipotent embryonic stem and germ cells. Oct 4 is the only factor that cannot be replace by an other factor of the POU family to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells. | ||
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The POU domain is a bipartite domain present in all Pou proteins. It consists of two subdomains, called the POU-specific domain and the POU homeodomain, connected by a flexible linker, variable in length. | The POU domain is a bipartite domain present in all Pou proteins. It consists of two subdomains, called the POU-specific domain and the POU homeodomain, connected by a flexible linker, variable in length. | ||
Flexibility of the linker enables the two subdomains to contact the DNA-binding site independently of each other. The other region of the protein show no specificity of structure or function. | Flexibility of the linker enables the two subdomains to contact the DNA-binding site independently of each other. The other region of the protein show no specificity of structure or function. | ||