Sandbox Reserved 811: Difference between revisions
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<Structure load='3b8e' size='500' frame='true' align='right' caption='Crystal structure of the sodium-potassium pump' scene='Insert optional scene name here' /> | <Structure load='3b8e' size='500' frame='true' align='right' caption='Crystal structure of the sodium-potassium pump' scene='Insert optional scene name here' /> | ||
'''Na+,K+-ATPase''' is a transmembrane protein which generates an electrochemical gradient for sodium and potassium ions using the hydrolysis of ATP as energy source. This pump exchanges 3Na+ for 2K+ (out) consuming ATP. | |||
It belongs to the family of P-type ATPase, also known as E1-E2 ATPases, which are phosphorylated on an Aspartateresidue during the transport cycle. | It belongs to the family of P-type ATPase, also known as E1-E2 ATPases, which are phosphorylated on an Aspartateresidue during the transport cycle. | ||
It is vital to animal cells to their volume and intracellular pH regulation, to their homeostasis as for electrical excitability. Depending on the cell type pumps allow the formation of a membrane potential or the transport of molecules through the membrane due to the established ionic concentration gradients. These gradients provide energy for other secondary active transports. | It is vital to animal cells to their volume and intracellular pH regulation, to their homeostasis as for electrical excitability. Depending on the cell type pumps allow the formation of a membrane potential or the transport of molecules through the membrane due to the established ionic concentration gradients. These gradients provide energy for other secondary active transports. | ||