4j7y: Difference between revisions
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{{STRUCTURE_4j7y| PDB=4j7y | SCENE= }} | {{STRUCTURE_4j7y| PDB=4j7y | SCENE= }} | ||
===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis=== | ===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis=== | ||
{{ABSTRACT_PUBMED_24366866}} | |||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
[[4j7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Y OCA]. | [[4j7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Y OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024366866</ref><references group="xtra"/><references/> | |||
[[Category: Haeggstrom, J Z.]] | [[Category: Haeggstrom, J Z.]] | ||
[[Category: Niegowski, D.]] | [[Category: Niegowski, D.]] | ||
Revision as of 08:59, 22 January 2014
Human LTC4 synthase in complex with product analogs - implications for enzyme catalysisHuman LTC4 synthase in complex with product analogs - implications for enzyme catalysis
Template:ABSTRACT PUBMED 24366866
DiseaseDisease
[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
FunctionFunction
[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
About this StructureAbout this Structure
4j7y is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggstrom JZ. Crystal structures of Leukotriene C4 synthase in complex with product analogs, implications for the enzyme mechanism. J Biol Chem. 2013 Dec 23. PMID:24366866 doi:http://dx.doi.org/10.1074/jbc.M113.534628