Sandbox Reserved 827: Difference between revisions
Léa Faivre (talk | contribs) |
Léa Faivre (talk | contribs) |
||
| Line 21: | Line 21: | ||
'''Interaction with viral proteins :''' | '''Interaction with viral proteins :''' | ||
TBK1 is the target of some viral proteins such as VP35 from Ebola virus, or the P protein from Borna virus. Those proteins inhibit TBK1. Normally, TBK1 is responsible for virus-induced phosphorylations that lead to the cellular antiviral state. Therefore, the inhibition of the kinase prevents the establishment of such a cellular state. | TBK1 is the target of some viral proteins such as VP35 from Ebola virus, or the P protein from Borna virus. Those proteins inhibit TBK1. Normally, TBK1 is responsible for virus-induced phosphorylations that lead to the cellular antiviral state. Therefore, the inhibition of the kinase prevents the establishment of such a cellular state. Since TBK1 is involved into the virus entrance following reaction, targeting TBK1 is a great solution for the viruses to prevent the reactions from the cell. | ||
""Oncology :"" | |||
In case of some cancers, the permanent activation of TBK1 may be responsible of the proliferation of the cancerous cells. Since the substrates of TBK1 are involved in the proliferation pathway when phosphorylated, this permanent activation is a reason of the non apoptosis state of cells, and therefore of their proliferation. | |||
== References == | == References == | ||
Q05127 | Q05127 | ||