Keratins: Difference between revisions
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Deleted Fig. 1 and moved its caption to Fig. 3. The editing is to correct the page after the move to HTML5 standard that does not allow multiple applets on the page. |
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Note: This entry on keratins has been featured in Biochem. Mol. Biol. Educ. <ref name="Hanukoglu-2013">PMID:24265184</ref>. | Note: This entry on keratins has been featured in Biochem. Mol. Biol. Educ. <ref name="Hanukoglu-2013">PMID:24265184</ref>. | ||
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==Secondary structures of keratins== | ==Secondary structures of keratins== | ||
[[Image:Keratin-secondary-structure-1000px.png|600px|right|thumb| Fig. | [[Image:Keratin-secondary-structure-1000px.png|600px|right|thumb| Fig. 1. The locations of the α-helical domains (1A, 1B, 2A and 2B) in the central rod of a keratin subunit.]] | ||
The first model of alpha-helix was proposed by Pauling based on the crystallography of wool fibers <ref>PMID:12966187</ref> that were shown to have long helical segments <ref>PMID:6072928</ref>. | The first model of alpha-helix was proposed by Pauling based on the crystallography of wool fibers <ref>PMID:12966187</ref> that were shown to have long helical segments <ref>PMID:6072928</ref>. | ||
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==Bonds that hold the coiled-coil structure== | ==Bonds that hold the coiled-coil structure== | ||
<Structure load='3TNU' size='600' frame='true' align='right' caption='Fig. | <Structure load='3TNU' size='600' frame='true' align='right' caption='Fig. 2. Crystal structure of the 2B helical domain of coiled-coil dimer of type I keratin K14 (chain A) and type II keratin K5 (chain B) (residues Ser332-Gly421 of K14 and Thr382-Gly476 of K5). PDB ID: [[3tnu]]. | ||
Please click the green colored links in the text in order to view highlighted features of the structure.' /> | |||
The basic building unit of keratin filaments is a hetero-dimer of a type I and a type II keratin. | The basic building unit of keratin filaments is a hetero-dimer of a type I and a type II keratin. | ||