Gp120: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='' size='450' side='right' scene='Journal:JBSD:41/Cv/1' caption='HIV Gp120 (green) complex with human T-cell surface glycoprotein CD4 (yellow) (PDB code [[1rzj]])'> | <StructureSection load='' size='450' side='right' scene='Journal:JBSD:41/Cv/1' caption='HIV Gp120 (green) complex with human T-cell surface glycoprotein CD4 (yellow) (PDB code [[1rzj]])'> | ||
'''Glycoprotein Gp120''', named for its molecular weight, is found on the surface of HIV envelope. Gp120 is associated with Gp41. It is involved in the binding of HIV to CD4 receptors thus attaching the virus to the host cell. For more details see<br /> | '''Glycoprotein Gp120''', named for its molecular weight, is found on the surface of HIV envelope. Gp120 is associated with Gp41. It is involved in the binding of HIV to CD4 receptors thus attaching the virus to the host cell. In HIV the third variable loop (V3) residues 296-331 of Gp120 allows the virus to infect human immune cells. For more details see<br /> | ||
*[[Hiv env proteins]]<br /> | *[[Hiv env proteins]]<br /> | ||
*[[VRC01 gp120 complex]]. | *[[VRC01 gp120 complex]]. | ||
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[[3dnl]], [[3dnn]], [[3dno]], [[3tgq]], [[3tgr]], [[3tgt]], [[3tih]] - Gp120 core<br /> | [[3dnl]], [[3dnn]], [[3dno]], [[3tgq]], [[3tgr]], [[3tgt]], [[3tih]] - Gp120 core<br /> | ||
[[1meq]] – GP120 C5 domain – NMR<br /> | [[1meq]] – GP120 C5 domain – NMR<br /> | ||
[[1niz]], [[1nj0]] - GP120 V3 loop – NMR | [[1niz]], [[1nj0]], [[2esx]], [[2esz]], [[1u6u]], [[1u6v]] - GP120 V3 loop – NMR<br /> | ||
[[4jpj]] - Gp120 outer domain<br /> | |||
===Gp120 binary complex=== | ===Gp120 binary complex=== | ||
[[2ny7]] - Gp120 core (mutant) + antibody | [[3idx]], [[3idy]], [[2ny7]]. [[4jdt]] - Gp120 core (mutant) + antibody <br /> | ||
[[ | [[3se8]], [[3se9]], [[3hi1]], [[3rjq]], [[4jkp]], [[4jm2]], [[4lss]], [[4lsv]] - Gp120 + antibody<br /> | ||
[[3hi1]] | |||
[[ | |||
[[3ngb]] - Gp120 + antibody VRC01<br /> | [[3ngb]] - Gp120 + antibody VRC01<br /> | ||
[[ | [[4i3r]], [[4i3s]] - Gp120 outer domain + antibody VRC-PG04<br /> | ||
[[4jan]], [[4lst]] - Gp120 Clade C + antibody <br /> | |||
[[4jb9]], [[4lsp]], [[4lsq]], [[4lsr]], [[4lsu]] - Gp120 Clade A/E + antibody <br /> | |||
[[4jpj]] - Gp120 Clade A + antibody <br /> | |||
[[4jpw]] - Gp120 Clade A (mutant) + antibody <br /> | |||
[[3u2s]] - Gp120 V1V2 region + antibody PG9<br /> | [[3u2s]] - Gp120 V1V2 region + antibody PG9<br /> | ||
[[3tgs]], [[4dko]], [[4dkp]], [[4dkq]], [[4dkr]] - Gp120 core + piperidine derivative | [[3tgs]], [[4dko]], [[4dkp]], [[4dkq]], [[4dkr]] - Gp120 core + piperidine derivative<br /> | ||
[[4dku]], [[4dkv]] - Gp120 core (mutant) + CD4 mimetic<br /> | |||
[[4jzw]], [[4jzz]], [[4k0a]], [[4ka2]] - Gp120 core + CD4 mimetic miniprotein<br /> | |||
===Gp120 ternary complex=== | ===Gp120 ternary complex=== | ||
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[[3jwd]], [[3jwo]] - Gp120 core + hCD4 N terminal + antibody 48D<br /> | [[3jwd]], [[3jwo]] - Gp120 core + hCD4 N terminal + antibody 48D<br /> | ||
[[2i5y]], [[2i60]] - Gp120 core + hCD4 N terminal + antibody 17B<br /> | [[2i5y]], [[2i60]] - Gp120 core + hCD4 N terminal + antibody 17B<br /> | ||
[[4laj]] - Gp120 core + CD4 mimetic miniprotein + antibody<br /> | |||
===Gp120 from SIV=== | ===Gp120 from SIV=== | ||
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<references/> | <references/> | ||
[[Category:Topic Page]] | |||