GMP synthase

GMP synthase (GMPS) catalyzes the conversion of xantosine 5’-phosphate, ATP, glutamine and water to glutamate, GMP, AMP and diphosphate. GMPS is active in purine and glutamate metabolism. 3D structures of GMP synthase Updated on 05-May-2025 1wl8, 2d7j – PhGMPS subunit A – Pyrococcus horikoshii 2dpl, 3a4i - PhGMPS subunit B 2ywb – TtGMPS – Thermus thermophilus 3tqi – GMPS – Coxiella burnetii 1kxj – TmGMPS – Thermotoga maritima 2a9v – GMPS – Thermoplasma acidophilum 2vpi – hGMPS glutaminase domain – human 2vxo - hGMPS + xantosine 5’-phosphate 2ywc – TtGMPS + xantosine 5’-phosphate 2iss – TmGMPS subunit PDXT + PLP biosynthesis lyase PDXS 1gpm – GMPS + pyrophosphate + AMP – Escherichia coli

spinqualitylabelsall models Structure of human GMP synthase dimer complex with xantosine 5-phosphate (stick model) and sulfate (PDB entry 2vxo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image