4nah: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4nah| PDB=4nah | SCENE= }} | |||
===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)=== | |||
{{ABSTRACT_PUBMED_24041904}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity). | |||
==About this Structure== | |||
[[4nah]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAH OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024041904</ref><references group="xtra"/><references/> | |||
[[Category: Pantetheine-phosphate adenylyltransferase]] | |||
[[Category: Lahiri, S D.]] | |||
[[Category: Phosphopanthetheine]] | |||
[[Category: Phosphopanthetheine adenylyltransferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 16:45, 12 March 2014
Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)
Template:ABSTRACT PUBMED 24041904
FunctionFunction
[COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
About this StructureAbout this Structure
4nah is a 6 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. , Epub 2013 Sep 16. PMID:24041904 doi:http://dx.doi.org/10.1128/AAC.01661-13