3wn7: Difference between revisions
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{{STRUCTURE_3wn7| PDB=3wn7 | SCENE= }} | |||
===Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> [[http://www.uniprot.org/uniprot/NF2L2_MOUSE NF2L2_MOUSE]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:9887101</ref> | |||
==About this Structure== | |||
[[3wn7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WN7 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Fukutomi, T.]] | |||
[[Category: Mizushima, T.]] | |||
[[Category: Ohuchi, N.]] | |||
[[Category: Takagi, K.]] | |||
[[Category: Yamamoto, M.]] | |||
[[Category: Beta-propeller]] | |||
[[Category: Degron]] | |||
[[Category: Kelch motif]] | |||
[[Category: Transcription]] | |||
Revision as of 13:22, 25 December 2013
Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factorCrystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor
FunctionFunction
[KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).[1] [2] [NF2L2_MOUSE] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.[3]
About this StructureAbout this Structure
3wn7 is a 4 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999 Jan 1;13(1):76-86. PMID:9887101
- ↑ McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem. 2003 Jun 13;278(24):21592-600. Epub 2003 Apr 7. PMID:12682069 doi:10.1074/jbc.M300931200
- ↑ Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999 Jan 1;13(1):76-86. PMID:9887101