Estrogen receptor: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='1gwr' size='450' side='right' scene='' caption='Human estrogen receptor-ligand binding domain (grey and green) complex with transcription intermediate factor-2 peptide (pink and yellow) and estradiol (PDB code [[1gwr]])'> | <StructureSection load='1gwr' size='450' side='right' scene='' caption='Human estrogen receptor-ligand binding domain (grey and green) complex with transcription intermediate factor-2 peptide (pink and yellow) and estradiol (PDB code [[1gwr]])'> | ||
[[Image:2yat.png|left|200px|thumb|Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex [[2yat]]]] | [[Image:2yat.png|left|200px|thumb|Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex [[2yat]]]] | ||
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'''Estrogen receptor α ligand binding domain''' | '''Estrogen receptor α ligand binding domain''' | ||
[[3ltx]] - ERα LBD – pacific oyster<br /> | [[3ltx]], [[4n1y]] - ERα LBD – pacific oyster<br /> | ||
[[1a52]], [[1g50]] - hERα LBD - human<br /> | [[1a52]], [[1g50]] - hERα LBD - human<br /> | ||
[[1ere]], [[1qku]] - hERα LBD + EST<BR /> | [[1ere]], [[1qku]] - hERα LBD + EST<BR /> | ||
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[[1uom]], [[2ayr]], [[2q70]], [[2qe4]], [[2pog]], [[2r6w]], [[2r6y]], [[2qxs]] - hERα LBD (mutant) + ligand<br /> | [[1uom]], [[2ayr]], [[2q70]], [[2qe4]], [[2pog]], [[2r6w]], [[2r6y]], [[2qxs]] - hERα LBD (mutant) + ligand<br /> | ||
[[1err]], [[3ert]], [[1sj0]], [[1yim]], [[1r5k]], [[1xp1]], [[1xp6]], [[1xp9]], [[1xpc]], [[1xqc]], [[1yin]], [[2ouz]], [[2iog]], [[2iok]], [[3dt3]], [[3os8]], [[3os9]], [[3osa ]] - hERα LBD + ligand<br /> | [[1err]], [[3ert]], [[1sj0]], [[1yim]], [[1r5k]], [[1xp1]], [[1xp6]], [[1xp9]], [[1xpc]], [[1xqc]], [[1yin]], [[2ouz]], [[2iog]], [[2iok]], [[3dt3]], [[3os8]], [[3os9]], [[3osa ]] - hERα LBD + ligand<br /> | ||
[[2bj4]], [[2jf9]], [[2jfa]] - hERα LBD + peptide antagonist<br /> | [[2bj4]], [[2jf9]], [[2jfa]], [[1pcg]] - hERα LBD + peptide antagonist<br /> | ||
[[2yja]] - hERα LBD + stapled peptide<br /> | [[2yja]] - hERα LBD + stapled peptide<br /> | ||
[[2yat]] - hERα LBD (mutant) + EST derivative<br /> | [[2yat]] - hERα LBD (mutant) + EST derivative<br /> | ||
[[3uuc]] - hERα LBD + bisphenol<br /> | |||
''ERα LBD ternary complex with steroid receptor coactivator peptide'' | ''ERα LBD ternary complex with steroid receptor coactivator peptide'' | ||
[[2b23]] - hERα LBD (mutant) + nuclear receptor coactivator peptide<br /> | [[2b23]], [[3uu7]], [[3uua]], [[3uud]] - hERα LBD (mutant) + nuclear receptor coactivator peptide<br /> | ||
[[3erd]], [[1l2i]] - hERα LBD + nuclear receptor coactivator peptide + nonsteroidal EST<BR /> | [[3erd]], [[1l2i]] - hERα LBD + nuclear receptor coactivator peptide + nonsteroidal EST<BR /> | ||
[[1gwr]] - hERα LBD + nuclear receptor coactivator peptide + EST<BR /> | [[1gwr]] - hERα LBD + nuclear receptor coactivator peptide + EST<BR /> | ||
[[3q95]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + EST<BR /> | [[3q95]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + EST<BR /> | ||
[[4dma]], [[4iu7]], [[4iui]], [[4iv2]], [[4iv4]], [[4ivw]], [[4ivy]], [[4iw6]], [[4iw8]], [[4iwc]], [[4iwf]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + inhibitor<br /> | |||
[[2g5o]] - hERα LBD + nuclear receptor coactivator peptide + EST derivative<br /> | [[2g5o]] - hERα LBD + nuclear receptor coactivator peptide + EST derivative<br /> | ||
[[2p15]], [[2qgt]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + EST derivative<br /> | [[2p15]], [[2qgt]] - hERα LBD (mutant) + nuclear receptor coactivator peptide + EST derivative<br /> | ||
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[[1qkn]], [[1hj1]] - ERβ LBD + ligand – rat<br /> | [[1qkn]], [[1hj1]] - ERβ LBD + ligand – rat<br /> | ||
[[1nde]], [[1u3q]], [[1u3r]], [[1u3s]], [[2giu]], [[2i0g]], [[2i0j]], [[2jj3]], [[2z4b]], [[2qtu]] - hERβ LBD + ligand<br /> | [[1nde]], [[1u3q]], [[1u3r]], [[1u3s]], [[2giu]], [[2i0g]], [[2i0j]], [[2jj3]], [[2z4b]], [[2qtu]] - hERβ LBD + ligand<br /> | ||
[[2yly]] - hERβ LBD + sulfonamide agonist<br /> | |||
[[2fsz]] - hERβ LBD (mutant) + ligand<br /> | [[2fsz]] - hERβ LBD (mutant) + ligand<br /> | ||
[[2yja]] - hERβ LBD + stapled peptide | [[2yja]] - hERβ LBD + stapled peptide<br /> | ||
[[4j24]], [[4j26]] - hERβ LBD + peptide<br /> | |||
''ERβ LBD ternary complex with steroid receptor coactivator peptide'' | ''ERβ LBD ternary complex with steroid receptor coactivator peptide'' | ||