Sandbox Reserved 774: Difference between revisions

The region around the <scene name='56/564050/Active_sites_zoom/1' target=1>active site</scene> has potential consequences for substrate binding. For Hpa2, there exists a pocket adjacent to the active site which is sealed off on two sides by the second Hpa2 monomer in each dimer. This pocket restricts the conformation of a polypeptide backbone in the vicinity of the active site. Therefore, Hpa2 is able to distinguish between potential substrate, whereby the only lysine side-chains that may enter the active site are those with surrounding polypeptides that can adopt a conformation with the ability to fit through the pocket. <ref name=Shiva/> <Structure load='1QSM' size='350' frame='true' align='right' caption='Hpa2 + AcCoA, showing: co-factor, backbone, β-strands, active site, α-helices.' scene='Insert optional scene name here' />