User:Alisha, Deepa, Pamiz/Sandbox 1: Difference between revisions

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[[Image:eso.jpg|300px|left|thumb|'''2D Structure & Biochemical Parameters of Esomeprazole''' Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole.
[[Image:eso.jpg|300px|left|thumb|'''2D Structure & Biochemical Parameters of Esomeprazole''' Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole.
]]'''Esomeprazole''' is the (S) enantiomer of Omeprazole. Esomperazole is a '''Proton Pump Inhibitor (PPI)''' that binds to '''H+/K+-ATPase''' and inhibits the secretion of gastric acid from parietal cells into the lumen of the stomach. Esomeprazole’s commercial brand name, Nexium, is used to treat Gastro-esophageal Reflux Disease (GERD), peptic and gastric ulcers, and Zollinger-Ellison syndrome.[CITATION??]
]]'''Esomeprazole''' is the (S) enantiomer of Omeprazole. Esomperazole is a '''Proton Pump Inhibitor (PPI)''' that binds to '''H+/K+-ATPase''' and inhibits the secretion of gastric acid from parietal cells into the lumen of the stomach. Esomeprazole’s commercial brand name, Nexium, is used to treat Gastro-esophageal Reflux Disease (GERD), peptic and gastric ulcers, and Zollinger-Ellison syndrome.[CITATION??]
Ulcers caused by the bacterium ''Helicobacter pylori'' can be treated using Esomeprazole in conjunction with proper antibiotics.1 Gastric acid is released through the H+/K+-ATPase pump, which is the final step in acid release.2 Esomeprazole is a specific, irreversible inhibitor of the pump.2                                                                   
Ulcers caused by the bacterium ''Helicobacter pylori'' can be treated using Esomeprazole in conjunction with proper antibiotics. <ref>[Mayo Clinic. Esomeprazole (Oral Route). http://www.mayoclinic.com/health/drug-information/DR603283 (accessed November 11, 2013).]Gastric acid is released through the H+/K+-ATPase pump, which is the final step in acid release.2 Esomeprazole is a specific, irreversible inhibitor of the pump.2                                                                   
   
   
                                           [[Image:PPI gif.gif]]
                                           [[Image:PPI gif.gif]]
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