Chengfeng Ren/Sandbox1: Difference between revisions
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==IFN Categories and IFNβ-1a sources== | =='''IFN Categories and IFNβ-1a sources'''== | ||
Interferons (IFNs) are a family of helical cytokines that mediate | Interferons (IFNs) are a family of helical cytokines that mediate | ||
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[[Image:IFN categories.jpg]] | [[Image:IFN categories.jpg]] | ||
==Structure info. of IFNβ-1a== | =='''Structure info. of IFNβ-1a'''== | ||
IFNβ-1a consisting of 166 amino acids, around 20KDa. It has 5 helixs. | IFNβ-1a consisting of 166 amino acids, around 20KDa. It has 5 helixs. | ||
<Structure load='1au1' size='500' frame='true' align='right' caption='IFN structure from PDB' scene='IFN scene_structure' /> | <Structure load='1au1' size='500' frame='true' align='right' caption='IFN structure from PDB' scene='IFN scene_structure' /> | ||
<scene name='56/566498/Ifn_beta_1a_scene_structure/1'>IFN beta 1a structure</scene> | <scene name='56/566498/Ifn_beta_1a_scene_structure/1'>IFN beta 1a structure</scene> | ||
==IFNβ-1a biological activity and therapeutic effects== | =='''IFNβ-1a biological activity and therapeutic effects'''== | ||
IFNβ-1a as well as other family of IFNs has a variety of biological activities, inluding antiviral, antiproliferative, and immune modulatory activities in response to biological and chemical stimuli. | IFNβ-1a as well as other family of IFNs has a variety of biological activities, inluding antiviral, antiproliferative, and immune modulatory activities in response to biological and chemical stimuli. | ||
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The commercial available drug format is [http://http://www.avonex.com/ Avonex].(Please refer to the drug guide before using it) | The commercial available drug format is [http://http://www.avonex.com/ Avonex].(Please refer to the drug guide before using it) | ||
==Mechanism of action for IFNβ-1a== | =='''Mechanism of action for IFNβ-1a'''== | ||
IFNβis encoded by a single gene | IFNβis encoded by a single gene | ||
with no introns (and hence, no splice variants), and no reported | with no introns (and hence, no splice variants), and no reported | ||