Sandbox Reserved 771: Difference between revisions
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==Reaction Mechanism== | ==Reaction Mechanism== | ||
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Glutathione Synthetase is the key enzyme involved in the ATP-dependent condensation of γ-Glutamylcysteine and glycine to form Glutathione during the second step of the glutathione biosynthesis pathway. The ATP-dependence of the catalysis qualifies GSS for inclusion into the ligase enzyme family. Further, a Hill constant of ~0.67 indicates that GSS exhibits negative cooperativity towards the substrate γ-Glutamylcysteine. | Glutathione Synthetase is the key enzyme involved in the ATP-dependent condensation of γ-Glutamylcysteine and glycine to form Glutathione during the second step of the glutathione biosynthesis pathway. The ATP-dependence of the catalysis qualifies GSS for inclusion into the ligase enzyme family. Further, a Hill constant of ~0.67 indicates that GSS exhibits negative cooperativity towards the substrate γ-Glutamylcysteine. | ||