Catabolite control protein: Difference between revisions
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<StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (grey) complex with Hpr (khaki) and sulfate (PDB entry [[2fep]])' scene=''> | <StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (grey) complex with Hpr (khaki) and sulfate (PDB entry [[2fep]])' scene=''> | ||
'''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins | '''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription. | ||
==3D structures of catabolite control protein== | ==3D structures of catabolite control protein== | ||
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===CcpA binary complex=== | ===CcpA binary complex=== | ||
[[2oen]] - BmCcpA + phosphocarrier protein | [[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> | ||
[[2fep]] - BsCcpA + phosphocarrier protein | [[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> | ||
===CcpA ternary complex=== | ===CcpA ternary complex=== | ||
[[1rzr]] – BmCcpA + phosphocarrier protein | [[1rzr]] – BmCcpA + phosphocarrier protein HPr + DNA <br /> | ||
[[2nzu]] - BmCcpA + phosphocarrier protein | [[2nzu]] - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate <br /> | ||
[[2nzv]] - BmCcpA + phosphocarrier protein | [[2nzv]] - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate <br /> | ||
[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | [[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | ||
[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein | [[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:58, 2 December 2013
<StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (grey) complex with Hpr (khaki) and sulfate (PDB entry 2fep)' scene=>
Catabolite control protein (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.
3D structures of catabolite control protein3D structures of catabolite control protein
Updated on 02-December-2013
2jcg, 2hsg - BmCcpA – Bacillus megaterium
1sxg, 1sxh, 1sxi – BmCcpA (mutant)
2o20 - CcpA (mutant) – Streptococcus lactis
CcpA binary complexCcpA binary complex
2oen - BmCcpA + phosphocarrier protein HPr
2fep - BsCcpA + phosphocarrier protein HPr – Bacillus subtilis
CcpA ternary complexCcpA ternary complex
1rzr – BmCcpA + phosphocarrier protein HPr + DNA
2nzu - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate
2nzv - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate
1zvv – BsCcpA + catabolite repression Crh + DNA
3oqm, 3oqn, 3oqo - BsCcpA + phosphocarrier protein HPr + DNA