RuBisCO: Difference between revisions
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{{STRUCTURE_1rcx| PDB=1rcx | SIZE=400| SCENE= |right|CAPTION=Spinach RuBisCO 8 large and 8 small chains complex with substrate ribulose-1,5- bisphosphate, [[1rcx]] }} | {{STRUCTURE_1rcx| PDB=1rcx | SIZE=400| SCENE= |right|CAPTION=Spinach RuBisCO 8 large and 8 small chains complex with substrate ribulose-1,5- bisphosphate, [[1rcx]] }} | ||
'''Ribulose-1,5-bisphosphate carboxylase oxygenase – RuBisCO''' (RBCO) catalyzes the first step in carbon fixation. | '''Ribulose-1,5-bisphosphate carboxylase oxygenase – RuBisCO''' (RBCO) catalyzes the first step in carbon fixation. RBCO carboxylates or oxygenates ribulose-1,5-bisphosphate (RUBP) with CO<sub>2</sub> or O<sub>2</sub>, respectively. RBCO from flowering plants usually consists of eight large subunits and eight small subunits. 2-carboxylarabinitol-1,5-bisphosphate (2-CABP) is an inhibitor of RCBO. Some additional details in [[Ribulose-1,5-bisphosphate carboxylase/oxygenase]]. | ||
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== Quaternery Structure == | == Quaternery Structure == | ||
The Rubisco <scene name='46/463261/Rubisco_spacefill_holoenzyme/1'>holoenzyme</scene> is shown in spacefill with its 8 large subunits in shades of blue and and its 8 small subunits in shades of yellow. The large subunits arranged in head-to-toe pairs like staves in a barrel and the small subunits are arranged at the ends of the barrel. The function of the small subunits is not understood. Each <scene name='46/463261/Rubisco_lsu_pair/3'>pair of large subunits</scene> has <scene name='46/463261/Rubisco_lsu_pair/4'>two active sites</scene> | The Rubisco <scene name='46/463261/Rubisco_spacefill_holoenzyme/1'>holoenzyme</scene> is shown in spacefill with its 8 large subunits in shades of blue and and its 8 small subunits in shades of yellow. The large subunits are arranged in head-to-toe pairs like staves in a barrel and the small subunits are arranged at the ends of the barrel. The large subunits contain the active sites and the function of the small subunits is not understood. | ||
== Active Site Structure == | |||
Each <scene name='46/463261/Rubisco_lsu_pair/3'>pair of large subunits</scene>, has <scene name='46/463261/Rubisco_lsu_pair/4'>two active sites</scene> located in their interface. The subunits are shown in cartoon and the active sites are occupied by RUBP in CPK spacefill). | |||
The active site of each subunit is formed by an α-β barrel located in the N-terminal lobe. Here the <scene name='46/463261/Rubisco_lsu_pair/5'>secondary structure of one of the subunits is shown</scene>, and here is the α-β barrel of that subunit. | |||