2qqh: Difference between revisions
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[[Image:2qqh.jpg|left|200px]] | [[Image:2qqh.jpg|left|200px]] | ||
'''Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense''' | {{Structure | ||
|PDB= 2qqh |SIZE=350|CAPTION= <scene name='initialview01'>2qqh</scene>, resolution 2.50Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | |||
|ACTIVITY= | |||
|GENE= C8A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2QQH is a [ | 2QQH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQH OCA]. | ||
==Reference== | ==Reference== | ||
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense., Hadders MA, Beringer DX, Gros P, Science. 2007 Sep 14;317(5844):1552-4. PMID:[http:// | Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense., Hadders MA, Beringer DX, Gros P, Science. 2007 Sep 14;317(5844):1552-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17872444 17872444] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: NI]] | [[Category: NI]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: cleavage on pair of basic | [[Category: cleavage on pair of basic residue]] | ||
[[Category: complement alternate pathway]] | [[Category: complement alternate pathway]] | ||
[[Category: complement pathway]] | [[Category: complement pathway]] | ||
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[[Category: secreted]] | [[Category: secreted]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:28:29 2008'' | ||
Revision as of 19:28, 20 March 2008
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| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | C8A (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense
OverviewOverview
Membrane attack is important for mammalian immune defense against invading microorganisms and infected host cells. Proteins of the complement membrane attack complex (MAC) and the protein perforin share a common MACPF domain that is responsible for membrane insertion and pore formation. We determined the crystal structure of the MACPF domain of complement component C8alpha at 2.5 angstrom resolution and show that it is structurally homologous to the bacterial, pore-forming, cholesterol-dependent cytolysins. The structure displays two regions that (in the bacterial cytolysins) refold into transmembrane beta hairpins, forming the lining of a barrel pore. Local hydrophobicity explains why C8alpha is the first complement protein to insert into the membrane. The size of the MACPF domain is consistent with known C9 pore sizes. These data imply that these mammalian and bacterial cytolytic proteins share a common mechanism of membrane insertion.
DiseaseDisease
Known disease associated with this structure: C8 deficiency, type I OMIM:[120950]
About this StructureAbout this Structure
2QQH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense., Hadders MA, Beringer DX, Gros P, Science. 2007 Sep 14;317(5844):1552-4. PMID:17872444
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Single protein
- Gros, P.
- Hadders, M A.
- NI
- SO4
- Cleavage on pair of basic residue
- Complement alternate pathway
- Complement pathway
- Cytolysis
- Egf-like domain
- Glycoprotein
- Immune response
- Immune system
- Innate immunity
- Macpf
- Membrane attack complex
- Membrane perforation
- Membrane protein
- Polymorphism
- Secreted