2qc8: Difference between revisions
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[[Image:2qc8.jpg|left|200px]] | [[Image:2qc8.jpg|left|200px]] | ||
'''Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate''' | {{Structure | ||
|PDB= 2qc8 |SIZE=350|CAPTION= <scene name='initialview01'>2qc8</scene>, resolution 2.60Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE PHOSPHATE'>P3S</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] | |||
|GENE= GLUL, GLNS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2QC8 is a [ | 2QC8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QC8 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design., Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL, J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:[http:// | Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design., Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL, J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18005987 18005987] | ||
[[Category: Glutamate--ammonia ligase]] | [[Category: Glutamate--ammonia ligase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: ligase]] | [[Category: ligase]] | ||
[[Category: sgc]] | [[Category: sgc]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
[[Category: structural genomics consortium]] | [[Category: structural genomics consortium]] | ||
[[Category: synthetase]] | [[Category: synthetase]] | ||
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