2qc8: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:
[[Image:2qc8.jpg|left|200px]]<br /><applet load="2qc8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2qc8.jpg|left|200px]]
caption="2qc8, resolution 2.60&Aring;" />
 
'''Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate'''<br />
{{Structure
|PDB= 2qc8 |SIZE=350|CAPTION= <scene name='initialview01'>2qc8</scene>, resolution 2.60&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE PHOSPHATE'>P3S</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2]
|GENE= GLUL, GLNS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate'''
 


==Overview==
==Overview==
Line 10: Line 19:


==About this Structure==
==About this Structure==
2QC8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=P3S:'>P3S</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QC8 OCA].  
2QC8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QC8 OCA].  


==Reference==
==Reference==
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design., Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL, J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18005987 18005987]
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design., Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL, J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18005987 18005987]
[[Category: Glutamate--ammonia ligase]]
[[Category: Glutamate--ammonia ligase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 51: Line 60:
[[Category: ligase]]
[[Category: ligase]]
[[Category: sgc]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: structural genomics consortium]]
[[Category: synthetase]]
[[Category: synthetase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:38:01 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:24:13 2008''

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA