4c53: Difference between revisions

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-{{STRUCTURE_4c53|  PDB=4c53  |  SCENE=  }}
+==Crystal Structure of Guanarito virus GP2 in the post-fusion conformation==
-===Crystal Structure of Guanarito virus GP2 in the post-fusion conformation===
+<StructureSection load='4c53' size='340' side='right' caption='[[4c53]], [[Resolution|resolution]] 4.14&Aring;' scene=''>
-{{ABSTRACT_PUBMED_24049182}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4c53]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gtov Gtov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C53 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c53 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c53 RCSB], [http://www.ebi.ac.uk/pdbsum/4c53 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1 A-resolution, in the post-fusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class-I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion.
-==About this Structure==
+Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation.,Parsy ML, Harlos K, Huiskonen JT, Bowden TA J Virol. 2013 Sep 18. PMID:24049182<ref>PMID:24049182</ref>
-[[4c53]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gtov Gtov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C53 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024049182</ref><references group="xtra"/><references/>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Gtov]]
-[[Category: Bowden, T A.]]
+[[Category: Bowden, T A]]
-[[Category: Harlos, K.]]
+[[Category: Harlos, K]]
-[[Category: Huiskonen, J T.]]
+[[Category: Huiskonen, J T]]
-[[Category: Parsy, M.]]
+[[Category: Parsy, M]]
 [[Category: Arenavirus]]
 [[Category: Fusion glycoprotein]]