Sandbox Reserved 824: Difference between revisions

Revision as of 14:48, 2 January 2014

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.

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Context / Work in ProgressContext / Work in Progress

SRP54 is a 54kDa protein part of the Signal Recognition Particle (SRP). SRP54 homologous proteins can be referred to as Ffh (Fifty Four Homologous)*.

SRP is a ribonucleoprotein particle essential for the translation and integration in membranes of signal peptide-bearing proteins. SRP is composed of an RNA backbone, on which bind different proteins.

For example Mammalian SRP are formed of the RNA 7S and SRN 9-14-19-54-68-72*.

SRP54 and regions of RNA 7S are highly conserved in every organism and it was found that these two components are sufficient to form a minimal SRP*.

The role of SRP is to :

Bind signal peptide bearing proteins at the beginning of their translation by the ribosome (at this step we call the ribosome and the protein it began to translate the Ribosome Nascent Chain – RNC)
Stop protein elongation
Dock the RNC to a SRP Receptor (SR) and insert the protein into a translocon channel. This final step is GTP-dependant.

SRP54 is responsible for the signal peptide binding and the GTP-dependant interaction with SR. This protein is therefore essential in the SRP mechanism resulting in the integration of proteins into membranes or their secretion.

asterisque = references aux publis, faire le lien avec les publis cites en fin d’article

StructureStructure

Domaines N, G, M / Interaction N-G => Domaine NG pour activité GTPase / Mention du domaine NG très similaire de SR alpha Domaine M avec partie rigide en c-term, partie flexible en n-term et grossièrement leurs fonctions

FonctionsFonctions

Lien avec la structure, explications des intéractions en fonction des structures etc ...

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Hamelin Baptiste, Grégoire de Clavière

@@ Line 2: / Line 2: @@
 {{Sandbox_Reserved_ESBS}}
 <!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
+==Context / Work in Progress==
+SRP54 is a 54kDa protein part of the Signal Recognition Particle (SRP).
+SRP54 homologous proteins can be referred to as Ffh (Fifty Four Homologous)*.
+SRP is a ribonucleoprotein particle essential for the translation and integration in membranes of signal peptide-bearing proteins.
+SRP is composed of an RNA backbone, on which bind different proteins.
+For example Mammalian SRP are formed of the RNA 7S and SRN 9-14-19-54-68-72*.
+SRP54 and regions of RNA 7S are highly conserved in every organism and it was found that these two components are sufficient to form a minimal SRP*.
+The role of SRP is to :
+:* Bind signal peptide bearing proteins at the beginning of their translation by the ribosome (at this step we call the ribosome and the protein it began to translate the Ribosome Nascent Chain – RNC)
+:* Stop protein elongation
+:* Dock the RNC to a SRP Receptor (SR) and insert the protein into a translocon channel. This final step is GTP-dependant.
+SRP54 is responsible for the signal peptide binding and the GTP-dependant interaction with SR.
+This protein is therefore essential in the SRP mechanism resulting in the integration of proteins into membranes or their secretion.
+asterisque = references aux publis, faire le lien avec les publis cites en fin d’article
+==Structure==
+Domaines N, G, M /
+Interaction N-G => Domaine NG pour activité GTPase / Mention du domaine NG très similaire de SR alpha
+Domaine M avec partie rigide en c-term, partie flexible en n-term et grossièrement leurs fonctions
+==Fonctions==
+Lien avec la structure, explications des intéractions en fonction des structures etc ...