Single stranded binding protein: Difference between revisions
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Single-stranded DNA (ssDNA) is utilized primarily during the course of major aspects of DNA metabolism such as replication, recombination and repair <ref>PMID: 2087220</ref>. In addition to stabilizing ssDNA, SSB proteins also bind to and control the function of many other proteins that are involved in all of three of these major DNA metabolic processes. During DNA replication, SSB molecules bind to the newly separated individual DNA strands, keeping the strands separated by holding them in place so that each strand can serve as a template for new DNA synthesis<ref>Berg JM, Tymoczko JL, Stryer L. ''Biochemistry''. 6th edition. New York: W H Freeman; 2006.</ref>. | Single-stranded DNA (ssDNA) is utilized primarily during the course of major aspects of DNA metabolism such as replication, recombination and repair <ref>PMID: 2087220</ref>. In addition to stabilizing ssDNA, SSB proteins also bind to and control the function of many other proteins that are involved in all of three of these major DNA metabolic processes. During DNA replication, SSB molecules bind to the newly separated individual DNA strands, keeping the strands separated by holding them in place so that each strand can serve as a template for new DNA synthesis<ref>Berg JM, Tymoczko JL, Stryer L. ''Biochemistry''. 6th edition. New York: W H Freeman; 2006.</ref>. | ||
==Structure of E. coli SSB== | ==Structure of ''E. coli'' SSB== | ||
<StructureSection load='1eyg' size='400' side='right' frame='true' caption='Structure of Single Stranded DNA-Binding Protein bound to ssDNA (PDB entry [[1eyg]])' scene=''> | <StructureSection load='1eyg' size='400' side='right' frame='true' caption='Structure of Single Stranded DNA-Binding Protein bound to ssDNA (PDB entry [[1eyg]])' scene=''> | ||