Single stranded binding protein: Difference between revisions
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SSB consists is a homotetramer that has a DNA binding domain which binds to a single strand of DNA. The tetramers consist of α-helices, β-sheets, and random coils. Each subunit contains an <scene name='56/566528/Alpha_helices/3'>α-helix</scene> and several <scene name='56/566528/Beta_sheets/1'>β-sheets</scene>. The secondary structure also includes a NH2 terminus, which consists of multiple positively charged amino acids. The DNA-binding domain lies within 115 amino acid residues from this terminus <ref>PMID: 2087220</ref>. The COOH terminus includes many acidic amino acids. | SSB consists is a homotetramer that has a DNA binding domain which binds to a single strand of DNA. The tetramers consist of α-helices, β-sheets, and random coils. Each subunit contains an <scene name='56/566528/Alpha_helices/3'>α-helix</scene> and several <scene name='56/566528/Beta_sheets/1'>β-sheets</scene>. The secondary structure also includes a NH2 terminus, which consists of multiple positively charged amino acids. The DNA-binding domain lies within 115 amino acid residues from this terminus <ref>PMID: 2087220</ref>. The COOH terminus includes many acidic amino acids. | ||
==Binding Interactions in the Active Site== | ===Binding Interactions in the Active Site=== | ||
<scene name='56/566528/Labeled_phe/1'>Phe56</scene> is an important DNA binding site. It has been shown to be the site for cross-linking. | <scene name='56/566528/Labeled_phe/1'>Phe56</scene> is an important DNA binding site. It has been shown to be the site for cross-linking. | ||