3zcf: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[3zcf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3zcf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCF OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024099549</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024099549</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Hough, M A.]] | [[Category: Hough, M A.]] | ||
[[Category: Rajagopal, B S.]] | [[Category: Rajagopal, B S.]] | ||
Revision as of 15:33, 11 December 2013
Structure of recombinant human cytochrome cStructure of recombinant human cytochrome c
Template:ABSTRACT PUBMED 24099549
DiseaseDisease
[CYC_HUMAN] Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.[1]
FunctionFunction
[CYC_HUMAN] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
About this StructureAbout this Structure
3zcf is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Rajagopal BS, Edzuma AN, Hough MA, Blundell KL, Kagan VE, Kapralov AA, Fraser LA, Butt JN, Silkstone GG, Wilson MT, Svistunenko DA, Worrall JA. The hydrogen peroxide induced radical behaviour in human cytochrome c phospholipid complexes: Implications for the enhanced pro-apoptotic activity of the G41S mutant. Biochem J. 2013 Oct 8. PMID:24099549 doi:http://dx.doi.org/10.1042/BJ20130758
- ↑ Morison IM, Cramer Borde EM, Cheesman EJ, Cheong PL, Holyoake AJ, Fichelson S, Weeks RJ, Lo A, Davies SM, Wilbanks SM, Fagerlund RD, Ludgate MW, da Silva Tatley FM, Coker MS, Bockett NA, Hughes G, Pippig DA, Smith MP, Capron C, Ledgerwood EC. A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nat Genet. 2008 Apr;40(4):387-9. Epub 2008 Mar 16. PMID:18345000 doi:ng.103