Succinate Dehydrogenase: Difference between revisions

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Michael Vick, David Canner, Michal Harel, Alexander Berchansky

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 <StructureSection load='3ae1' size='500' side='right' caption='Succinate dehydrogenase containing flavoprotein subunit (grey), iron-sulfur subunit (green), cytochrome B560 subunit (pink) and cytochrome B small subunit (yellow), FAD, Fe2S2, Fe4S4 and Fe3S4 complex with protoporphyrin, malonate, benzamide derivative and α-phosphatidyl-β-oleoyl-γ-palmitoyl-phosphatidylethanolamine, [[3ae1]] ' scene=''>
-[[Image:Succinate Dehydrogenase.png|left|250px]][[Succinate Dehydrogenase]] (PDB = [[2wdv]] with empty ubiquinone binding site; PDB = [[1nek]] with ubiquinone bound), also called succinate-coenzyme Q reductase (SQR) or Complex II, is a tetrameric enzyme found in the cell membrane of some bacteria and the inner mitochondrial membrane of mammalian cells. It is classified as an α+β protein, as it contains <scene name='Michael_Vick_Sandbox_2/2wdv_sec_structure/1'>segregated regions</scene> of α helices and antiparallel β sheets. It is involved in two aspects of digestion; it catalyzes the oxidation of succinate to fumarate in the [[The_Citric_Acid_Cycle|citric acid cycle]] by simultaneously reducing ubiquinone to ubiquinol in the electron transport chain <ref>PMID:14672929</ref>.
+[[Image:Succinate Dehydrogenase.png|left|250px]][[Succinate Dehydrogenase]] (PDB = [[2wdv]] with empty ubiquinone binding site; PDB = [[1nek]] with ubiquinone bound), also called '''succinate-coenzyme Q reductase''' (SQR) or '''Complex II''', is a tetrameric enzyme found in the cell membrane of some bacteria and the inner mitochondrial membrane of mammalian cells. It is classified as an α+β protein, as it contains <scene name='Michael_Vick_Sandbox_2/2wdv_sec_structure/1'>segregated regions</scene> of α helices and antiparallel β sheets. It is involved in two aspects of digestion; it catalyzes the oxidation of succinate to fumarate in the [[The_Citric_Acid_Cycle|citric acid cycle]] by simultaneously reducing ubiquinone to ubiquinol in the electron transport chain <ref>PMID:14672929</ref>.
 __NOTOC__
 ===Structure===