15.5kD/Snu13/L7Ae protein: Difference between revisions

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Kelly Hrywkiw, Alexander Berchansky, Wayne Decatur

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 The structure itself may not the most important aspect when comparing the homologues, rather the amino acid composition.  There are five amino acids located at the RNA binding region that are conserved within each of archaea and eukarya, however vary between the two.  One such amino acid lies towards the N-terminal side of the RNA binding region, in L7Ae it is Lys26 (Methanocaldococcus jannashii), and in 15.5kD it is Gln34.  Towards the C-terminal side of the RNA binding region located in loop 9 lie the four remaining residues Leu-Glu-Aal-Ala (L7Ae) and <scene name='Sandbox_503/Valserargpro/2'>Val95-Ser96-Arg97-Pro98 </scene>(15.5kD).  It is the difference between these amino acids that allow L7Ae to bind the kink-loop motif<ref name ="m-g"/>.
 </StructureSection>
-=Additional Resources=
-*[http://www.rcsb.org/pdb/explore/explore.do?structureId=1e7k CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT, in the RCSB Protein Data Bank]
+==See Also==
+* [[Kink-turn motif]]
+* [[RNA motifs]]
+* [[Ribosome]]
+* [[Large Ribosomal Subunit of Haloarcula|The Large Ribosomal Subunit]]
+* [[Ribozyme]]
+* [[Group I intron]]
+* [[Azoarcus group I intron]]
+* [[1go1]], [[1go0]], [[1w3e]] and [[1h7m]] – the ''Thermococcus celer'' ribosomal protein L30<ref>PMID: 12627951</ref><ref>PMID: 12824494</ref>
+* A-minor motif
+* The adenosine wedge motif<ref>PMID: 20038632</ref>
+* The G-ribo motif<ref>PMID: 17283211</ref>
+* The lonepair triloop motif<ref>PMID: 12473452</ref>
+* RNA ribose zipper<ref>PMID: 12096903</ref>
+=References=
+<References/>
+=Additional External Resources=
+*[http://www.rcsb.org/pdb/explore/explore.do?structureId=1e7k CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 snRNA FRAGMENT, in the RCSB Protein Data Bank]
 *[http://www.rcsb.org/pdb/explore/explore.do?structureId=2ozb Structure of a human Prp31-15.5K-U4 snRNA complex, in the RCSB Protein Data Bank]
 *[http://www.rcsb.org/pdb/explore/explore.do?structureId=1zwz Structural comparison of Yeast snoRNP and splicesomal protein snu13p with its homologs, in the RCSB Protein Data Bank]
 *[http://www.rcsb.org/pdb/explore/explore.do?structureId=1rlg Molecular basis of Box C/D RNA-protein interaction: co-crystal structure of the Archaeal sRNP intiation complex, in the RCSB Protein Data Bank]
 *[http://www.rcsb.org/pdb/explore/explore.do?structureId=1pxw Crystal structure of L7Ae sRNP core protein from Pyrococcus abyssii, in the RCSB Protein Data Bank]
-=References=
-<References/>