4mvt: Difference between revisions
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==Crystal structure of SUMO E3 Ligase PIAS3== | |||
=== | <StructureSection load='4mvt' size='340' side='right' caption='[[4mvt]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4mvt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIAS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvt RCSB], [http://www.ebi.ac.uk/pdbsum/4mvt PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PIAS3_HUMAN PIAS3_HUMAN]] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.<ref>PMID:9388184</ref> | [[http://www.uniprot.org/uniprot/PIAS3_HUMAN PIAS3_HUMAN]] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.<ref>PMID:9388184</ref> | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
<references | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Dong, A | [[Category: Dong, A]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Hu, J | [[Category: Hu, J]] | ||
[[Category: Li, Y | [[Category: Li, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tempel, W | [[Category: Tempel, W]] | ||
[[Category: Tong, Y | [[Category: Tong, Y]] | ||
[[Category: E3 ligase]] | [[Category: E3 ligase]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
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[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Sp-ring domain]] | [[Category: Sp-ring domain]] | ||
[[Category: Sumo]] | [[Category: Sumo]] | ||