4c9y: Difference between revisions
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{{STRUCTURE_4c9y| PDB=4c9y | SCENE= }} | |||
===Structural Basis for the microtubule binding of the human kinetochore Ska complex=== | |||
{{ABSTRACT_PUBMED_24413531}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/SKA1_HUMAN SKA1_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref> | |||
==About this Structure== | |||
[[4c9y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9Y OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024413531</ref><references group="xtra"/><references/> | |||
[[Category: Abad, M.]] | |||
[[Category: Jayachandran, U.]] | |||
[[Category: Jeyaprakash, A A.]] | |||
[[Category: Madhumalar, A.]] | |||
[[Category: Medina, B.]] | |||
[[Category: Nigg, E A.]] | |||
[[Category: Plasberg-Hill, C.]] | |||
[[Category: Rappsilber, J.]] | |||
[[Category: Redli, P M.]] | |||
[[Category: Santamaria, A.]] | |||
[[Category: Zou, J.]] | |||
[[Category: Cell cycle]] | |||
[[Category: Cell divison]] | |||
[[Category: Kinetochore-microtubule attachment]] | |||
[[Category: Winged-helix domain]] | |||
Revision as of 09:55, 22 January 2014
Structural Basis for the microtubule binding of the human kinetochore Ska complexStructural Basis for the microtubule binding of the human kinetochore Ska complex
Template:ABSTRACT PUBMED 24413531
FunctionFunction
[SKA1_HUMAN] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.[1] [2]
About this StructureAbout this Structure
4c9y is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Abad MA, Medina B, Santamaria A, Zou J, Plasberg-Hill C, Madhumalar A, Jayachandran U, Redli PM, Rappsilber J, Nigg EA, Jeyaprakash AA. Structural basis for microtubule recognition by the human kinetochore Ska complex. Nat Commun. 2014 Jan 13;5:2964. doi: 10.1038/ncomms3964. PMID:24413531 doi:http://dx.doi.org/10.1038/ncomms3964
- ↑ Hanisch A, Sillje HH, Nigg EA. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J. 2006 Nov 29;25(23):5504-15. Epub 2006 Nov 9. PMID:17093495 doi:http://dx.doi.org/10.1038/sj.emboj.7601426
- ↑ Welburn JP, Grishchuk EL, Backer CB, Wilson-Kubalek EM, Yates JR 3rd, Cheeseman IM. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev Cell. 2009 Mar;16(3):374-85. PMID:19289083 doi:http://dx.doi.org/S1534-5807(09)00039-2