2otg: Difference between revisions
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[[Image:2otg.jpg|left|200px]] | [[Image:2otg.jpg|left|200px]] | ||
'''Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor''' | {{Structure | ||
|PDB= 2otg |SIZE=350|CAPTION= <scene name='initialview01'>2otg</scene>, resolution 3.120Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2OTG is a [ | 2OTG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Placopecten_magellanicus Placopecten magellanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTG OCA]. | ||
==Reference== | ==Reference== | ||
Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor., Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C, Structure. 2007 May;15(5):553-64. PMID:[http:// | Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor., Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C, Structure. 2007 May;15(5):553-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17502101 17502101] | ||
[[Category: Placopecten magellanicus]] | [[Category: Placopecten magellanicus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: rigor-like]] | [[Category: rigor-like]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:04:14 2008'' | ||
Revision as of 19:04, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor
OverviewOverview
Unlike processive cellular motors such as myosin V, whose structure has recently been determined in a "rigor-like" conformation, myosin II from contracting muscle filaments necessarily spends most of its time detached from actin. By using squid and sea scallop sources, however, we have now obtained similar rigor-like atomic structures for muscle myosin heads (S1). The significance of the hallmark closed actin-binding cleft in these crystal structures is supported here by actin/S1-binding studies. These structures reveal how different duty ratios, and hence cellular functions, of the myosin isoforms may be accounted for, in part, on the basis of detailed differences in interdomain contacts. Moreover, the rigor-like position of switch II turns out to be unique for myosin V. The overall arrangements of subdomains in the motor are relatively conserved in each of the known contractile states, and we explore qualitatively the energetics of these states.
About this StructureAbout this Structure
2OTG is a Protein complex structure of sequences from Placopecten magellanicus. Full crystallographic information is available from OCA.
ReferenceReference
Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor., Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C, Structure. 2007 May;15(5):553-64. PMID:17502101
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