Leucine transporter: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='3gwu' size='350' side='right' caption='Structure of leucine transporter complex with leucine, antidepressant and Na+ ion (in purple) (PDB entry [[3gwu]])' scene=''> | <StructureSection load='3gwu' size='350' side='right' caption='Structure of leucine transporter complex with leucine, antidepressant and Na+ ion (in purple) (PDB entry [[3gwu]])' scene=''> | ||
== Function == | |||
'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction | '''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>. | ||
==Relevance == | |||
LeuT is the target of many antidepressant and recreational drugs. | |||
==3D structures of leucine transporter== | ==3D structures of leucine transporter== | ||
| Line 17: | Line 20: | ||
[[3tt1]] – AaLeuT (mutant) + Na + antibody<br /> | [[3tt1]] – AaLeuT (mutant) + Na + antibody<br /> | ||
[[3tt3]] – AaLeuT (mutant) + antibody<br /> | [[3tt3]] – AaLeuT (mutant) + antibody<br /> | ||
== References == | |||
<references/> | |||