4lfx: Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
{{STRUCTURE_4lfx|  PDB=4lfx  |  SCENE=  }}
==X-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers==
===X-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers===
<StructureSection load='4lfx' size='340' side='right' caption='[[4lfx]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
{{ABSTRACT_PUBMED_24045294}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4lfx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LFX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j1a|4j1a]], [[4j1b|4j1b]], [[4lfp|4lfp]], [[4lgk|4lgk]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lfx RCSB], [http://www.ebi.ac.uk/pdbsum/4lfx PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.


==Function==
The mode of action of anticancer gold-based drugs: a structural perspective.,Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A Chem Commun (Camb). 2013 Sep 18. PMID:24045294<ref>PMID:24045294</ref>
[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4lfx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LFX OCA].
</div>


==Reference==
==See Also==
<ref group="xtra">PMID:024045294</ref><references group="xtra"/><references/>
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
[[Category: Gallus gallus]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chick]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
[[Category: Merlino, A.]]
[[Category: Merlino, A]]
[[Category: Vergara, A.]]
[[Category: Vergara, A]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/w/4lfx"