4c66: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4c66|  PDB=4c66  |  SCENE=  }}
+===Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains===
+{{ABSTRACT_PUBMED_24015967}}
-The entry 4c66 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-Authors: Chung, C., Mirguet, O.
+==Function==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Description: Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
+==About this Structure==
+[[4c66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C66 OCA].
+==Reference==
+<ref group="xtra">PMID:024015967</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Chung, C.]]
+[[Category: Mirguet, O.]]
+[[Category: Antagonist]]
+[[Category: Cell cycle]]
+[[Category: Epigenetic reader]]
+[[Category: Inhibitor]]
+[[Category: Transcription regulation]]