4m6q: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m6q|  PDB=4m6q  |  SCENE=  }}
+===Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
+{{ABSTRACT_PUBMED_24021463}}
-The entry 4m6q is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O' Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
+==About this Structure==
+[[4m6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6Q OCA].
-Description: Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
+==Reference==
+<ref group="xtra">PMID:024021463</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Bravo, B.]]
+[[Category: Brien, T O.]]
+[[Category: Dragovich, P S.]]
+[[Category: Feng, Y.]]
+[[Category: Giannetti, A M.]]
+[[Category: Gunzner-Toste, J.]]
+[[Category: Ho, Y.]]
+[[Category: Hua, R.]]
+[[Category: Liederer, B M.]]
+[[Category: Liu, Y.]]
+[[Category: Oeh, J.]]
+[[Category: Sampath, D.]]
+[[Category: Shen, Y.]]
+[[Category: Skelton, N.]]
+[[Category: Wang, C.]]
+[[Category: Wang, L.]]
+[[Category: Wang, W.]]
+[[Category: Wu, H.]]
+[[Category: Xiao, Y.]]
+[[Category: Yuen, P.]]
+[[Category: Zak, M.]]
+[[Category: Zhao, G.]]
+[[Category: Zhao, Q.]]
+[[Category: Zheng, X.]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]