3wi2: Difference between revisions
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{{STRUCTURE_3wi2| PDB=3wi2 | SCENE= }} | |||
===Crystal structure of PDE10A in complex with inhibitor=== | |||
{{ABSTRACT_PUBMED_24238902}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==About this Structure== | |||
[[3wi2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WI2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024238902</ref><references group="xtra"/><references/> | |||
[[Category: Amano, Y.]] | |||
[[Category: Cgmp binding]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Phosphodiesterase]] | |||
Revision as of 16:36, 11 December 2013
Crystal structure of PDE10A in complex with inhibitorCrystal structure of PDE10A in complex with inhibitor
Template:ABSTRACT PUBMED 24238902
FunctionFunction
[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]
About this StructureAbout this Structure
3wi2 is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hamaguchi W, Masuda N, Isomura M, Miyamoto S, Kikuchi S, Amano Y, Honbou K, Mihara T, Watanabe T. Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. Bioorg Med Chem. 2013 Dec 15;21(24):7612-23. doi: 10.1016/j.bmc.2013.10.035. Epub, 2013 Oct 31. PMID:24238902 doi:http://dx.doi.org/10.1016/j.bmc.2013.10.035