4mep: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4mep|  PDB=4mep  |  SCENE=  }}
===Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand===


The entry 4mep is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 


Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., Vidler, L.R., Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Hoelder, S., Knapp, S., Structural Genomics Consortium (SGC)
==Function==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand
==About this Structure==
[[4mep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MEP OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Brown, N.]]
[[Category: Delft, F von.]]
[[Category: Edwards, A M.]]
[[Category: Fedorov, O.]]
[[Category: Felletar, I.]]
[[Category: Filippakopoulos, P.]]
[[Category: Hoelder, S.]]
[[Category: Knapp, S.]]
[[Category: Martin, S.]]
[[Category: Picaud, S.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Vidler, L R.]]
[[Category: Weigelt, J.]]
[[Category: Brd]]
[[Category: Brd4]]
[[Category: Cap]]
[[Category: Hunk1]]
[[Category: Mcap]]
[[Category: Mitotic chromosome associated protein]]
[[Category: Sgc]]
[[Category: Small molecule inhibitor]]
[[Category: Structural genomics consortium]]
[[Category: Transcription-transcription inhibitor complex]]

Revision as of 11:22, 29 September 2013

Template:STRUCTURE 4mep

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligandCrystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand

DiseaseDisease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

FunctionFunction

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this StructureAbout this Structure

4mep is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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