4c3a: Difference between revisions
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{{STRUCTURE_4c3a| PDB=4c3a | SCENE= }} | |||
===Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amine=== | |||
{{ABSTRACT_PUBMED_24660051}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. | |||
==About this Structure== | |||
[[4c3a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3A OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024660051</ref><references group="xtra"/><references/> | |||
[[Category: Li, H.]] | |||
[[Category: Poulos, T L.]] | |||
[[Category: Inhibitor complex]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 12:23, 2 April 2014
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amineStructure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amine
Template:ABSTRACT PUBMED 24660051
FunctionFunction
[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
About this StructureAbout this Structure
4c3a is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Jing Q, Li H, Roman LJ, Martasek P, Poulos TL, Silverman RB. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. ACS Med Chem Lett. 2014 Jan 9;5(1):56-60. PMID:24660051 doi:http://dx.doi.org/10.1021/ml400381s