4mak: Difference between revisions
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{{STRUCTURE_4mak| PDB=4mak | SCENE= }} | |||
===Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref> | |||
==About this Structure== | |||
[[4mak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mg1655 Escherichia coli str. k-12 substr. mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAK OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Escherichia coli str. k-12 substr. mg1655]] | |||
[[Category: Brown, G.]] | |||
[[Category: Joachimiak, A.]] | |||
[[Category: MCSG, Midwest Center for Structural Genomics.]] | |||
[[Category: Nocek, B.]] | |||
[[Category: Skarina, T.]] | |||
[[Category: Yakunin, A.]] | |||
[[Category: Cas2]] | |||
[[Category: Crispr]] | |||
[[Category: Hydrolase]] | |||
[[Category: Mcsg]] | |||
[[Category: Midwest center for structural genomic]] | |||
[[Category: Psi-biology]] | |||
[[Category: Structural genomic]] | |||
Revision as of 14:02, 4 September 2013
Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coliCrystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli
FunctionFunction
[CAS2_ECOLI] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).[1]
About this StructureAbout this Structure
4mak is a 2 chain structure with sequence from Escherichia coli str. k-12 substr. mg1655. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Perez-Rodriguez R, Haitjema C, Huang Q, Nam KH, Bernardis S, Ke A, DeLisa MP. Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli. Mol Microbiol. 2011 Feb;79(3):584-99. doi: 10.1111/j.1365-2958.2010.07482.x. Epub, 2010 Dec 13. PMID:21255106 doi:10.1111/j.1365-2958.2010.07482.x