Exonuclease: Difference between revisions
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{{STRUCTURE_1fxx| PDB=1fxx | SIZE=400| SCENE= |right|CAPTION=E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion, [[1fxx]] }} | {{STRUCTURE_1fxx| PDB=1fxx | SIZE=400| SCENE= |right|CAPTION=E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion, [[1fxx]] }} | ||
'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII. | '''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII.<br /> | ||
* '''ExN-I''' cleaves single-stranded DNA.<br /> | |||
* '''ExN-II''' is associated with DNA polymerase.<br /> | |||
* '''ExN-III''' cleaves double-stranded DNA.<br /> | |||
* '''ExN-IV''' cleavage results in nucleoside monophosphate.<br /> | |||
* '''ExN-V''' cleaves linear double-stranded DNA.<br /> | |||
* '''ExN-VIII''' requires a free 5’ OH group for reacting.<br /> | |||
* '''ExN''' were found in human and yeast as well. | |||
== 3D Structures of exonuclease == | == 3D Structures of exonuclease == |