Exonuclease: Difference between revisions

Michal Harel (talk | contribs)
No edit summary
Michal Harel (talk | contribs)
No edit summary
Line 1: Line 1:
{{STRUCTURE_1fxx|  PDB=1fxx  | SIZE=400| SCENE= |right|CAPTION=E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion, [[1fxx]] }}
{{STRUCTURE_1fxx|  PDB=1fxx  | SIZE=400| SCENE= |right|CAPTION=E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion, [[1fxx]] }}


'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain.  In E. coli there are ExN I to VIII. ExN-I cleaves single-stranded DNA; ExN-II is associated with DNA polymerase; ExN-III cleaves double-stranded DNA; ExN-IV cleavage results in nucleoside monophosphate; ExN-V cleaves linear double-stranded DNA; ExN-VIII requires a free 5’ OH group for reacting. ExN were found in human and yeast as well.
'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain.  In E. coli there are ExN I to VIII.<br />
 
* '''ExN-I''' cleaves single-stranded DNA.<br />
{{TOC limit|limit=2}}
* '''ExN-II''' is associated with DNA polymerase.<br />
* '''ExN-III''' cleaves double-stranded DNA.<br />
* '''ExN-IV''' cleavage results in nucleoside monophosphate.<br />
* '''ExN-V''' cleaves linear double-stranded DNA.<br />
* '''ExN-VIII''' requires a free 5’ OH group for reacting.<br />
* '''ExN''' were found in human and yeast as well.


== 3D Structures of exonuclease ==
== 3D Structures of exonuclease ==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman