User:Alice Harmon/Sandbox 1: Difference between revisions

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the activation loop, the P+1 loop.

<scene name='55/555705/Subdomainviii/1'>Subdomain VIII</scene> contains the APE motif. The <scene name='55/555705/Ape/1'>glutamate in this motif (blue ball and stick) </scene>glutamate in this motif forms a salt bridge with an arginine (yellow ball and stick) in in Subdomain X1. This salt bridge is critical for forming the stable kinase core. In many protein kinases there is a phosphorylatable residue seven to ten residues upstream of the APE motif. In PKA it is a <scene name='55/555705/Phosphothreonine/1'>phosphothreonine</scene>, which forms an ionic bond with the arginine in the HRDLKPEN motif of the catalytic loop and helps to position it for catalysis.

<scene name='55/555705/Subdomainviii/1'>Subdomain VIII</scene> contains the APE motif. The <scene name='55/555705/Ape/1'>glutamate in this motif (blue ball and stick) </scene>glutamate in this motif forms a salt bridge with an arginine (yellow ball and stick) in in Subdomain X1. This salt bridge is critical for forming the stable kinase core. In many protein kinases there is a phosphorylatable residue seven to ten residues upstream of the APE motif. In PKA it is a <scene name='55/555705/Phosphothreonine/1'>phosphothreonine</scene> (blue ball and stick with the phosphate in CPK), which forms an ionic bond with the arginine (yellow ball and stick) in the HRDLKPEN motif of the catalytic loop and helps to position it for catalysis.

<scene name='55/555705/Subdomainix/1'>Subdomain IX</scene>

<scene name='55/555705/Subdomainx/1'>Subdomain X</scene> and <scene name='55/555705/Subdomainxi/1'>Subdomain XI</scene> bind substrate proteins and forms the kinase core.

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 the activation loop, the P+1 loop.
-<scene name='55/555705/Subdomainviii/1'>Subdomain VIII</scene> contains the APE motif. The <scene name='55/555705/Ape/1'>glutamate in this motif (blue ball and stick) </scene>glutamate in this motif forms a salt bridge with an arginine (yellow ball and stick) in in Subdomain X1. This salt bridge is critical for forming the stable kinase core. In many protein kinases there is a phosphorylatable residue seven to ten residues upstream of the APE motif. In PKA it is a <scene name='55/555705/Phosphothreonine/1'>phosphothreonine</scene>, which forms an ionic bond with the arginine in the HRDLKPEN motif of the catalytic loop and helps to position it for catalysis.
+<scene name='55/555705/Subdomainviii/1'>Subdomain VIII</scene> contains the APE motif. The <scene name='55/555705/Ape/1'>glutamate in this motif (blue ball and stick) </scene>glutamate in this motif forms a salt bridge with an arginine (yellow ball and stick) in in Subdomain X1. This salt bridge is critical for forming the stable kinase core. In many protein kinases there is a phosphorylatable residue seven to ten residues upstream of the APE motif. In PKA it is a <scene name='55/555705/Phosphothreonine/1'>phosphothreonine</scene> (blue ball and stick with the phosphate in CPK), which forms an ionic bond with the arginine (yellow ball and stick) in the HRDLKPEN motif of the catalytic loop and helps to position it for catalysis.
 <scene name='55/555705/Subdomainix/1'>Subdomain IX</scene>
 <scene name='55/555705/Subdomainx/1'>Subdomain X</scene> and <scene name='55/555705/Subdomainxi/1'>Subdomain XI</scene> bind substrate proteins and forms the kinase core.