4isq: Difference between revisions
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{{STRUCTURE_4isq| PDB=4isq | SCENE= }} | {{STRUCTURE_4isq| PDB=4isq | SCENE= }} | ||
===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I=== | ===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I=== | ||
{{ABSTRACT_PUBMED_23932591}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA]. | [[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023932591</ref><references group="xtra"/><references/> | |||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Berntsson, R P.A.]] | [[Category: Berntsson, R P.A.]] | ||
Revision as of 07:57, 10 October 2013
Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin IBinding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
Template:ABSTRACT PUBMED 23932591
FunctionFunction
[SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
About this StructureAbout this Structure
4isq is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P. Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II. Structure. 2013 Sep 3;21(9):1602-11. doi: 10.1016/j.str.2013.06.026. Epub 2013, Aug 8. PMID:23932591 doi:http://dx.doi.org/10.1016/j.str.2013.06.026