4c0y: Difference between revisions
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{{STRUCTURE_4c0y| PDB=4c0y | SCENE= }} | |||
===Cryo-EM reconstruction of empty enterovirus 71 in complex with a neutralizing antibody E18=== | |||
{{ABSTRACT_PUBMED_24469789}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/A9X4C2_9ENTO A9X4C2_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047] | |||
==About this Structure== | |||
[[4c0y]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_enterovirus_71 Human enterovirus 71] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0Y OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024469789</ref><references group="xtra"/><references/> | |||
[[Category: Human enterovirus 71]] | |||
[[Category: Mus musculus]] | |||
[[Category: Cardosa, J.]] | |||
[[Category: Kuhn, R J.]] | |||
[[Category: Perera, R.]] | |||
[[Category: Plevka, P.]] | |||
[[Category: Rossmann, M G.]] | |||
[[Category: Suksatu, A.]] | |||
[[Category: Antibody]] | |||
[[Category: E18]] | |||
[[Category: Ev71]] | |||
[[Category: Neutralizing]] | |||
[[Category: Pathogen]] | |||
[[Category: Virus-immune system complex]] | |||
Revision as of 14:21, 5 February 2014
Cryo-EM reconstruction of empty enterovirus 71 in complex with a neutralizing antibody E18Cryo-EM reconstruction of empty enterovirus 71 in complex with a neutralizing antibody E18
Template:ABSTRACT PUBMED 24469789
FunctionFunction
[A9X4C2_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
About this StructureAbout this Structure
4c0y is a 5 chain structure with sequence from Human enterovirus 71 and Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Plevka P, Lim PY, Perera R, Cardosa J, Suksatu A, Kuhn RJ, Rossmann MG. Neutralizing antibodies can initiate genome release from human enterovirus 71. Proc Natl Acad Sci U S A. 2014 Jan 27. PMID:24469789 doi:http://dx.doi.org/10.1073/pnas.1320624111