2jhp: Difference between revisions

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THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE

OverviewOverview

Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

About this StructureAbout this Structure

2JHP is a Single protein structure of sequence from Bluetongue virus 10 (isolate usa). Full crystallographic information is available from OCA.

ReferenceReference

Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654

Page seeded by OCA on Thu Mar 20 17:42:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2jhp.gif|left|200px]]<br /><applet load="2jhp" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2jhp.gif|left|200px]]
-caption="2jhp, resolution 2.50&Aring;" />
-'''THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE'''<br />
+ {{Structure
+|PDB= 2jhp |SIZE=350|CAPTION= <scene name='initialview01'>2jhp</scene>, resolution 2.50&Aring;
+|SITE= <scene name='pdbsite=AC1:Gun+Binding+Site+For+Chain+A'>AC1</scene>
+|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=GUN:GUANINE'>GUN</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-JHP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bluetongue_virus_10_(isolate_usa) Bluetongue virus 10 (isolate usa)] with <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=GUN:'>GUN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Gun+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHP OCA].
+JHP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bluetongue_virus_10_(isolate_usa) Bluetongue virus 10 (isolate usa)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHP OCA].
 ==Reference==
-Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17417654 17417654]
+Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17417654 17417654]
 [[Category: Bluetongue virus 10 (isolate usa)]]
 [[Category: Single protein]]
@@ Line 26: / Line 35: @@
 [[Category: virion protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:03:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:42:07 2008''