4lhu: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4lhu|  PDB=4lhu  |  SCENE=  }}
+===Crystal Structure of 9C2 TCR bound to CD1d===
-The entry 4lhu is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-Authors: Uldrich, A.P., Le Nours, J., Pellicci, D.G., Gras, S., Rossjohn, J., Godfrey, D.I.
+==Function==
+[[http://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref>  [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
-Description:
+==About this Structure==
+[[4lhu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHU OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Godfrey, D I.]]
+[[Category: Gras, S.]]
+[[Category: Nours, J Le.]]
+[[Category: Pellicci, D G.]]
+[[Category: Rossjohn, J.]]
+[[Category: Uldrich, A P.]]
+[[Category: Cd1d]]
+[[Category: Gammadelta tcr]]
+[[Category: Immune system]]
+[[Category: Lipid recognition]]
+[[Category: Nkt cell]]
+[[Category: Pbs-44]]