4lc7: Difference between revisions

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OCA

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-'''Unreleased structure'''
+{{STRUCTURE_4lc7|  PDB=4lc7  |  SCENE=  }}
+===Aminooxazoline inhibitor of BACE-1===
-The entry 4lc7 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Huestis, M.P., Liu, W., Volgraf, M., Purkey, H.E., Wu, C., Wang, W., Smith, D., Vigers, G.P.A., Dutcher, D., Hunt, K.W., Siu, M.
+==About this Structure==
+[[4lc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC7 OCA].
-Description: Aminooxazoline inhibitor of BACE-1
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Dutcher, D.]]
+[[Category: Huestis, M P.]]
+[[Category: Hunt, K W.]]
+[[Category: Liu, W.]]
+[[Category: Purkey, H E.]]
+[[Category: Siu, M.]]
+[[Category: Smith, D.]]
+[[Category: Vigers, G P.A.]]
+[[Category: Volgraf, M.]]
+[[Category: Wang, W.]]
+[[Category: Wu, C.]]
+[[Category: Aspartyl protease]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]