4l4z: Difference between revisions
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{{STRUCTURE_4l4z| PDB=4l4z | SCENE= }} | |||
===Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition=== | |||
{{ABSTRACT_PUBMED_24047255}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI]] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.<ref>PMID:15601708</ref> <ref>PMID:15743955</ref> <ref>PMID:17557827</ref> | |||
==About this Structure== | |||
[[4l4z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4Z OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024047255</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli k-12]] | |||
[[Category: Eo, Y.]] | |||
[[Category: Ha, J H.]] | |||
[[Category: Ryu, K S.]] | |||
[[Category: Dna binding]] | |||
[[Category: Dna transcriptional regulator]] | |||
[[Category: Phospho-ai-2 binding]] | |||
[[Category: Removed helix-turn-helix domain]] | |||
[[Category: Sorc/deor family]] | |||
[[Category: Transcription regulator]] | |||
Revision as of 10:48, 6 November 2013
Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognitionCrystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition
Template:ABSTRACT PUBMED 24047255
FunctionFunction
[LSRR_ECOLI] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.[1] [2] [3]
About this StructureAbout this Structure
4l4z is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ha JH, Eo Y, Grishaev A, Guo M, Smith JA, Sintim HO, Kim EH, Cheong HK, Bentley WE, Ryu KS. Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J Am Chem Soc. 2013 Oct 16;135(41):15526-35. doi: 10.1021/ja407068v. Epub 2013, Oct 1. PMID:24047255 doi:http://dx.doi.org/10.1021/ja407068v
- ↑ Xavier KB, Bassler BL. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol. 2005 Jan;187(1):238-48. PMID:15601708 doi:http://dx.doi.org/187/1/238
- ↑ Wang L, Hashimoto Y, Tsao CY, Valdes JJ, Bentley WE. Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli. J Bacteriol. 2005 Mar;187(6):2066-76. PMID:15743955 doi:http://dx.doi.org/187/6/2066
- ↑ Li J, Attila C, Wang L, Wood TK, Valdes JJ, Bentley WE. Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture. J Bacteriol. 2007 Aug;189(16):6011-20. Epub 2007 Jun 8. PMID:17557827 doi:http://dx.doi.org/JB.00014-07