4l29: Difference between revisions

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-'''Unreleased structure'''
+{{Large structure}}
+{{STRUCTURE_4l29|  PDB=4l29  |  SCENE=  }}
+===Structure of wtMHC class I with NY-ESO1 double mutant===
-The entry 4l29 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-Authors: Halabelian, L., Giorgetti, S., Bellotti, V., Bolognesi, M., Ricagno, S.
+==Function==
+[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
-Description: Structure of wtMHC class I with NY-ESO1 double mutant
+==About this Structure==
+[[4l29]] is a 42 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L29 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Bellotti, V.]]
+[[Category: Bolognesi, M.]]
+[[Category: Giorgetti, S.]]
+[[Category: Halabelian, L.]]
+[[Category: Ricagno, S.]]
+[[Category: Beta sandwitch]]
+[[Category: Beta-2 microglobulin]]
+[[Category: D76n variant]]
+[[Category: Hla_a0201]]
+[[Category: Immune system]]
+[[Category: Immunglobulin]]
+[[Category: Mhc]]
+[[Category: Ny-eso1]]