4ljp: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4ljp|  PDB=4ljp  |  SCENE=  }}
+===Structure of an active ligase (HOIP-H889A)/ubiquitin transfer complex===
-The entry 4ljp is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN]] E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref>
-Authors: Rana, R.R., Stieglitz, B., Koliopoulos, M.G., Morris-Davies, A.C., Christodoulou, E., Howell, S., Brown, N.R., Rittinger, K.
+==About this Structure==
+[[4ljp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LJP OCA].
-Description:
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Bos taurus]]
+[[Category: Homo sapiens]]
+[[Category: Brown, N R.]]
+[[Category: Christodoulou, E.]]
+[[Category: Howell, S.]]
+[[Category: Koliopoulos, M G.]]
+[[Category: Morris-Davies, A C.]]
+[[Category: Rana, R R.]]
+[[Category: Rittinger, K.]]
+[[Category: Stieglitz, B.]]
+[[Category: E3 ligase]]
+[[Category: E3 ligase-ubiquitin complex]]
+[[Category: Hoip]]
+[[Category: Ibr domain]]
+[[Category: Ligase]]
+[[Category: Rbr ligase]]
+[[Category: Ring domain]]
+[[Category: Rnf31]]
+[[Category: Ubiquitin]]
+[[Category: Zinc finger]]