4lh2: Difference between revisions
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{{STRUCTURE_4lh2| PDB=4lh2 | SCENE= }} | |||
===Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate=== | |||
{{ABSTRACT_PUBMED_23928095}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/AL4A1_MOUSE AL4A1_MOUSE]] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | |||
==About this Structure== | |||
[[4lh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023928095</ref><references group="xtra"/><references/> | |||
[[Category: 1-pyrroline-5-carboxylate dehydrogenase]] | |||
[[Category: Mus musculus]] | |||
[[Category: Pemberton, T A.]] | |||
[[Category: Tanner, J J.]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Proline catabolism]] | |||
[[Category: Rossmann fold]] | |||
[[Category: Substrate recognition]] | |||
Revision as of 10:27, 28 August 2013
Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinateStructure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate
Template:ABSTRACT PUBMED 23928095
FunctionFunction
[AL4A1_MOUSE] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).
About this StructureAbout this Structure
4lh2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Pemberton TA, Tanner JJ. Structural basis of substrate selectivity of Delta-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): Semialdehyde chain length. Arch Biochem Biophys. 2013 Aug 6. pii: S0003-9861(13)00231-2. doi:, 10.1016/j.abb.2013.07.024. PMID:23928095 doi:10.1016/j.abb.2013.07.024